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KMID : 0364219680110030083
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Korean Journal of Zoology
1968 Volume.11 No. 3 p.83 ~ p.84
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Dissimilarity between Human and Bacterial DNA
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Park In-Won
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Abstract
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An attempt was made to estimate the possible homology between human and bacterial DNA by the method of DNA-agar gel hybridization. HeLa DNA was embedded in the agar and 14C-DNA Xanthomonas pelargonii was used as bacterial DNA for the sheared fragments. No homology between human and bacterial DNA was detected. If homology exists at all, it can be estimated from the sensitivity of the method and assuming some 1,000 nucleotide pairs per cistron, the not more than 2x10^5 base pairs or 200 bacterial cistrons would be preserved in human DNA, corresponding to less than 0.01 per cent of the total human genome.
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